复方中药对腹水综合征肉鸡肝组织α-SMA、I型和III型胶原蛋白含量的作用

doi:10.11843/j.issn.0366-6964.2016.11.020

Abstract

Abstract:

The objective of this study was to investigate the changes of α-smooth muscle actin (α-SMA), collagen type I and collagen type III in liver of broilers with ascites syndrome (AS) and the prevention and treatment of the compound recipe of the traditional Chinese medicine (TCM) on AS. A total of 309 7-day-old Ross broilers were randomly divided into six groups, group None was bred with normal diet, the rest were bred with high-energy diet derived from standard diet added with 3% lard and 4% fish meal and 0.12% Na+ in drinking water at 9-11 ℃ to induce AS, group Control was given no medicine, compound recipe of the TCM groups (High, Middle, Low) were respectively given a dose of 2, 1, 0.5 mL•kg^-1 of the TCM in drinking water, and group L-Arg with 1% L-arginine in diet. The results showed that at 15, 25, 35 and 45 days of age, compared with group None, the incidence of AS, ascites heart index, heart index, lung index, liver index, the levels of α-SMA, collagen type I and collagen type III in liver of broilers in group Control were increased significantly (P<0.01 or P<0.05), and spleen index in group Control was decreased significantly (P<0.01 or P<0.05). Compared with group Control, the items above were all improved in compound recipe of the traditional Chinese medicine groups and group L-Arg (P<0.01 or P<0.05). The study showed the increases of the levels of α-SMA, collagen type I and collagen type III in liver of broilers participated in the pathogenesis of AS. The studied compound recipe of the traditional Chinese medicine with the role of tonifying qi-blood and activating qi to excrete water can prevent and treat AS of broilers effectively, and the mechanism was related to the decreases of compound recipe of the traditional Chinese medicine on the levels of α-SMA, collagen type I and collagen type III in liver of broilers with AS.

CLC Number:

S853.33

HAN Ye-chen, ZHANG Juan, WANG Jun-wu, YUN Shi-yu, WU Hai-ping, WEN Shuang, ZHAO Dong-dong, WANG Zhuo, SU Xiao-fei, ZHU Yu-bo, CHENG Jia, SUN Yao-gui, WANG Wen-kui, LI Hong-quan, DUAN Zhi-bian. The Effect of the Compound Recipe of the Traditional Chinese Medicine on Collagen in Liver of Broilers with Ascites Syndrome[J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2016, 47(11): 2310-2317.

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The Effect of the Compound Recipe of the Traditional Chinese Medicine on Collagen in Liver of Broilers with Ascites Syndrome

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